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Dharmendra S. Modha

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Archives for March 2011

Early Tagging of Cortical Networks Is Required for the Formation of Enduring Associative Memory

March 7, 2011 By dmodha

I read a thought-provoking article in Science (18 Feb 2011) by Edith Lesburguères, Oliviero L. Gobbo, Stéphanie Alaux-Cantin, Anne Hambucken, Pierre Trifilieff, and Bruno Bontempi.

Abstract: Although formation and stabilization of long-lasting associative memories are thought to require time-dependent coordinated hippocampal-cortical interactions, the underlying mechanisms remain unclear. Here, we present evidence that neurons in the rat cortex must undergo a “tagging process” upon encoding to ensure the progressive hippocampal-driven rewiring of cortical networks that support remote memory storage. This process was AMPA- and N-methyl-D-aspartate receptor–dependent, information-specific, and capable of modulating remote memory persistence by affecting the temporal dynamics of hippocampal-cortical interactions. Post-learning reinforcement of the tagging process via time-limited epigenetic modifications resulted in improved remote memory retrieval. Thus, early tagging of cortical networks is a crucial neurobiological process for remote memory formation whose functional properties fit the requirements imposed by the extended time scale of systems-level memory consolidation.

Filed Under: Brain-inspired Computing

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